Table 2

Neuropsychiatric symptoms and neuropsychological test performances in the premanifest and the motor manifest gene-expansion carriers
Premanifest HD gene-expansion carriers Motor manifest HD gene-expansion carriers Level of significance
N = 51 N = 56 p-value
Neuropsychiatric scales
SCL-90-Ra
   Global Severity Index 49.6 (10.1) 53.6(10.2) 0.041
   Somatization 50.5 (9.7) 50.5 (9.9) 0.979
   Obsessive-compulsive 49.5 (10.3) 57.25 (10.2) <0.001
   Interpersonal Sensitivity 47.9 (10.5) 51.2 (12.0) 0.134
   Depression 49.3 (10.5) 54.0 (9.0) 0.014
   Anxiety 50.1 (10.9) 53.0 (9.46) 0.141
   Anger-hostility 53.3 (11.6) 52.8 (12.7) 0.848
   Phobic anxiety 50.7 (11.1) 55.1 (12.8) 0.059
   Paranoid ideation 47.4 (9.7) 47.2 (9.6) 0.915
   Psychoticism 47.8 (9.2) 53.4 (10.9) 0.005
   Positive Symptoms Total 49.9 (10.0) 52.6 (9.1) 0.142
   Positive Symptoms Distress Index 52.6 (10.3) 55.7 (10.8) 0.141
HAM-17b 4.5 (4.6) 5.8 (3.7) 0.103
Neuropsychological tests
Trail Making Test A (seconds) 22.8 (5.2) 45.3 (21.2) <0.001
Trail Making Test B (seconds) 62.2 (16.7) 131.8 (55.5) <0.001
Symbol Digit Modalities Test (number correct) 49.6 (8.1) 28.3 (9.4) <0.001
Stroop interference (seconds) 119.0 (21.0) 193.5 (77.3) <0.001
Category verbal fluency 24.1 (4.2) 16.6 (6.4) <0.001
Lexical fluency, s-words 14.5 (3.9) 10.7 (5.1) <0.001
Lexical fluency, a-words 9.4 (3.9) 5.7 (3.1) <0.001
Reys Complex Figure Test, recall 24.3 (6.3) 18.3 (6.0) <0.001
Reys Complex Figure Test, copy 35.6 (1.0) 34.0 (2.4) <0.001
Block design (number correct) 11.9 (0.4) 10.8 (1.8) <0.001
Raven’s Advanced Progressive Matrices 9.5 (1.7) 6.5 (2.6) <0.001
Selective Reminding Test, immediate recall (number of errors) 12.49 (7.9) 28.17 (11.6) <0.001
Selective Reminding Test, delayed recall 7.57 (1.7) 6.02 (2.1) <0.001

aSymptom Checklist-90-R. Data shown as mean (SD). p values were calculated by independent sample t-tests. bHamilton Rating Scale for Depression-17.

Vinther-Jensen et al.

Vinther-Jensen et al. Orphanet Journal of Rare Diseases 2014 9:114   doi:10.1186/s13023-014-0114-8

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