Email updates

Keep up to date with the latest news and content from Orphanet Journal of Rare Diseases and BioMed Central.

Open Access Letter to the Editor

Can network biology unravel the aetiology of congenital hyperinsulinism?

Adam Stevens1, Karen E Cosgrove2, Raja Padidela1, Mars S Skae1, Peter E Clayton1, Indraneel Banerjee1 and Mark J Dunne2*

Author Affiliations

1 Department of Endocrinology, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, UK

2 Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK

For all author emails, please log on.

Orphanet Journal of Rare Diseases 2013, 8:21  doi:10.1186/1750-1172-8-21

Published: 8 February 2013

Abstract

Congenital Hyperinsulinism is a condition with a number of genetic causes, but for the majority of patients, the underlying aetiology is unknown. We present here a rational argument for the use of computational biology as a valuable resource for identifying new candidate genes which may cause disease and for understanding the complex mechanisms which define the pathophysiology of this rare disease.