Table 2

Prevalence of less common findings in the NIH cohort of patients with fibrous dysplasia

Other clinical findings

% patients1


Gastrointestinal

7

History of hepatitis2

4

Reflux2

5

Pancreatitis2

3

Polyps3

5

Cardiac

6

Tachycardia4

4

Aortic root dilatation (GH excess)5

2

Hematologic

1

Platelet dysfunction

1

Cancer

4

Thyroid6

1

Breast6

2

Bone6

1

Testicular6

1

Hyperparathyroid

1

Neuropsychiatric

9


1n = 140; 58 males, 82 females, 2appeared in childhood, common causes excluded, 3atypical, upper GI tract polyps, myxomatoid pathology more common, 4unexplained/not associated with hyperthyroidism, 5only seen in patients with growth hormone excess, 6all tumors bear Gsα mutation, adjacent normal tissue mutation negative.

Collins et al. Orphanet Journal of Rare Diseases 2012 7(Suppl 1):S4   doi:10.1186/1750-1172-7-S1-S4

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