The relative age at which any given aspect of the disease becomes clinically evident is depicted by a solid black bar. Preclinical disease is depicted by gray bars, and ages during which spontaneous resolution is possible for Cushing’s disease and phosphaturia are shown in open bars. The period of time during which abnormal menstruation can be expected is depicted by the stippled bar.
Collins et al. Orphanet Journal of Rare Diseases 2012 7(Suppl 1):S4 doi:10.1186/1750-1172-7-S1-S4