Table 3 |
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|
Genetic susceptibility factors for AIP and clinical implications. |
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|
Gene |
Polymorphism/genotype |
Implication |
Population |
|
|
|||
|
Human leukocyte antigen (HLA) |
DRB1*0405, DQB1*0401 |
Increased disease susceptibility |
Japanese |
|
Non-aspartic acids at DQβ1 57 |
Increased relapse risk |
Korean |
|
|
Cytotoxic T lymphocyte-antigen (CTLA-4) |
+49A |
Increased disease susceptibility |
Chinese |
|
+6230G/G |
Increased disease susceptibility |
Japanese |
|
|
+6230A |
Decreased disease susceptibility |
Japanese |
|
|
+49A/A, +6230A/A |
Increased relapse risk |
Japanese |
|
|
Tumour necrosis factor-α (TNF-α) |
-893A |
Other organ involvement |
Chinese |
|
Fc receptor-like 3 (FCRL3) |
-110A/A |
Increased disease susceptibility |
Japanese |
|
|
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|
Zen et al. Orphanet Journal of Rare Diseases 2011 6:82 doi:10.1186/1750-1172-6-82 |
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