Table 2

Treatments of patients with the Schnitzler syndrome before the use of anakinra

Treatment

Comment


Steroids

Suspensive, but usually requiring a high daily dosis (>40 mg equivalent of prednisolone) to achieve improvement


Non steroid anti-inflammatory drugs, most notably ibuprofen

Transient amelioration of fever and pain


Immunosuppressive drugs, including methotrexate, azathioprine, cyclophosphamide

Usually ineffective


Colchicine, dapsone

Transient improvement


Thalidomide

Anecdotic reports of efficiency


TNF-blocking agents

Ineffective


Immunoabsorption

Only a single report


Intravenous immunoglobulins

Ineffective


Rituximab

Ineffective


Anti-histamines

Usually ineffective, even on the skin rash


Phototherapy

Transient amelioration of skin rash


Peflacine

Efficient in some patients; recurrence if treatment is stopped.


Anakinra

Complete and sustained remission of all symptoms; recurrence if treatment is stopped


Lipsker Orphanet Journal of Rare Diseases 2010 5:38   doi:10.1186/1750-1172-5-38

Open Data