Table 2

Prevalence of individual symptoms of hypothyroidism at the time of diagnosis. (modified from: Alm et al. Brit Med J 289:1171-175, 1984 [13].)

Features listed in questionnaire

Group 1 (n = 215) Initial T4 ≤ 30 nmol/L %

with feature

Group 2 (n = 232) Initial T4 > 30 nmol/L %

with feature


Prolonged Jaundice

59

33**

Feeding Difficulty

35

16**

Lethargy

34

14**

Umbilical Hernia

32

18*

Macroglossia

25

12*

Constipation

18

10

Cold or mottled skin

18

10

Hypothermia

3

3

No symptoms

16

33**

Other clinical features reported:

Abnormal cry

7

6

Edema

5

3

Hypothyroid appearance

6

2

Hypotonia

3

3


**p < 0.001, *p < 0.01.

Rastogi and LaFranchi Orphanet Journal of Rare Diseases 2010 5:17   doi:10.1186/1750-1172-5-17

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