Triptans and troponin: a case report

doi:10.1186/1750-1172-4-15

Orphanet Journal of Rare Diseases

Volume 4

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Case Report

Triptans and troponin: a case report

Claudia R Weder and Markus Schneemann

Department of Internal Medicine, University Hospital of Zürich, Rämistrasse 100, CH-8091 Zürich, Switzerland

author email corresponding author email

Orphanet Journal of Rare Diseases 2009, 4:15doi:10.1186/1750-1172-4-15


Published:	18 June 2009

Abstract

This case report describes for the first time acute coronary syndrome in a 67-year old patient after oral intake of naratriptan for migraine. So far in the literature, only sumatriptan, zolmitriptan and frovatriptan have been described to cause acute coronary syndromes.

A 67-year old Swiss woman with thoracic pain after intake of 2.5 mg naratriptan presented with T-wave inversions in the ECG and a positive troponin-T at our hospital. Coronary angiography showed normal coronary arteries. Naratriptan-induced coronary vasospasms were thought to have caused the acute coronary syndrome.

Triptans should not be prescribed in patients with pre-existing coronary heart disease. However, triptans can also cause acute coronary syndromes in patients without coronary heart disease – as described in our case report. Severe or persistent thoracic pain after intake of triptans should therefore be investigated accordingly.