Figure 1.

A model of transport mechanisms in the DCT. Sodium-chloride (NaCl) enters the cell via the apical thiazide-sensitive NCC and leaves the cell through the basolateral Cl^- channel (ClC-Kb), and the Na⁺/K⁺-ATPase. Indicated also are the recently identified magnesium channel TRPM6 in the apical membrane, and a putative Na/Mg exchanger in the basolateral membrane.