Adaptive design methods in clinical trials – a review

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Review

Shein-Chung Chow¹ and Mark Chang²

¹Duke University School of Medicine, Durham, North Carolina, USA

²Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA

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Orphanet Journal of Rare Diseases 2008, 3:11doi:10.1186/1750-1172-3-11


Published:	2 May 2008

Additional file 1:

Response-adaptive randomization

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