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Main paraneoplastic neurological syndromes and associated antibodies |
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| Paraneoplastic neurological syndromes |
Frequency of paraneoplastic origin |
Main associated tumors |
Main frequent associated paraneoplastic antibodies |
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| LEMS |
60% |
SCLC |
VGCC-Ab* |
| Subacute cerebellar ataxia |
50% |
Ovary, breast SCLC Hodgkin's disease Others |
Yo-Ab (PCA1-Ab**) Hu-Ab (ANNA1-Ab**) CV2-Ab (CRMP5-Ab**) Tr-Ab Ma-Ab (Ta-Ab**) |
| Opsomyoclonus |
20% |
Neuroblastoma Breast, lung |
Hu-Ab (ANNA1-Ab**) Ri-Ab (ANNA2-Ab**) |
| Sensory neuronopathy |
20% |
SCLC |
Hu-Ab (ANNA1-Ab**) CV2-Ab (CRMP5-Ab**) |
| Limbic encephalitis |
20% |
SCLC Testicular SCLC |
Hu-Ab (ANNA1-Ab**) CV2-Ab (CRMP5-Ab**) Ma2-Ab (Ta-Ab**) Amphiphysin-Ab |
| Encephalomyelitis |
10% |
SCLC Others |
Hu-Ab (ANNA1-Ab**) CV2-Ab (CRMP5-Ab**) Amphiphysin-Ab Ma2-Ab (Ta-Ab**) |
| Retinopathy |
NA |
SCLC Melanoma |
Recoverin-Ab CV2-Ab (CRMP5-Ab**) Rod-bipolar-cell-Ab |
| Stiff-person syndrome |
20% |
Breast |
Amphiphysin-Ab |
| Chronic gastrointestinal pseudoobstruction |
NA |
SCLC |
Hu-Ab (ANNA1-Ab**) CV2-Ab (CRMP5-Ab**) |
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*VGCC-Ab are not really paraneoplastic antibodies because they are involved in LEMS but are not independent on the presence of a tumor **Alternative nomenclature which can be found in the literature | |||
Honnorat and Antoine Orphanet Journal of Rare Diseases 2007 2:22 doi:10.1186/1750-1172-2-22 |
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