Table 1

Criteria used in the Clinical Grading Scale for Malignant Hyperthermia

Clinical Finding

Manifestation


Respiratory acidosis

End-tidal CO2>55 mmHg; PaCO2>60 mm Hg

Cardiac involvement

Unexplained sinus tachycardia, ventricular tachycardia or ventricular fibrillation

Metabolic acidosis

Base deficit >8 m/Eql

pH<7.25

Muscle rigidity

Generalized rigidity; severe masseter muscle rigidity

Muscle breakdown

Serum creatine kinase concentration >20,000/L units; cola colored urine; excess myoglobin in urine or serum; plasma [K+] >6 mEq/L

Temperature increase

Rapidly increasing temperature; T >38.8°C

Other

Rapid reversal of MH signs with dantrolene. Elevated resting serum creatine kinase concentration.

Family history

Consistent with autosomal dominant inheritance


Rosenberg et al. Orphanet Journal of Rare Diseases 2007 2:21   doi:10.1186/1750-1172-2-21

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