Table 1 |
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Criteria used in the Clinical Grading Scale for Malignant Hyperthermia |
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Clinical Finding |
Manifestation |
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Respiratory acidosis |
End-tidal CO2>55 mmHg; PaCO2>60 mm Hg |
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Cardiac involvement |
Unexplained sinus tachycardia, ventricular tachycardia or ventricular fibrillation |
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Metabolic acidosis |
Base deficit >8 m/Eql pH<7.25 |
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Muscle rigidity |
Generalized rigidity; severe masseter muscle rigidity |
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Muscle breakdown |
Serum creatine kinase concentration >20,000/L units; cola colored urine; excess myoglobin in urine or serum; plasma [K+] >6 mEq/L |
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Temperature increase |
Rapidly increasing temperature; T >38.8°C |
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Other |
Rapid reversal of MH signs with dantrolene. Elevated resting serum creatine kinase concentration. |
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Family history |
Consistent with autosomal dominant inheritance |
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Rosenberg et al. Orphanet Journal of Rare Diseases 2007 2:21 doi:10.1186/1750-1172-2-21 |
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