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International retinoblastoma classification |
| Stage 0: Patients treated conservatively (subject to presurgical ophthalmologic classifications) |
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| Stage I: Eye enucleated, completely resected histologically |
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| Stage II: Eye enucleated, microscopic residual tumor |
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| Stage III: Regional extensiona |
| a) Overt orbital disease |
| b) Preauricular or cervical lymph node extension |
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| Stage IV: Metastatic disease |
| a) Hematogenous metastasis: |
| 1. single lesion |
| 2. multiple lesions |
| b) CNS extension: |
| 1. Prechiasmatic lesion |
| 2. CNS mass |
| 3. Leptomeningeal disease |
Aerts et al. Orphanet Journal of Rare Diseases 2006 1:31 doi:10.1186/1750-1172-1-31 |